PRIVENT Trial

Prevention of Recurrent urinary tract Infection in children with VEsicoureteric reflux and Normal renal tracts Trial

PRIVENT was an NHMRC funded, multicentre double blind randomised controlled trial designed to determine whether long-term antibiotics prevents urinary tract infection in children. Antibiotics are given daily to the children over 1 year in which investigators, pharmacy staff and outcome assessors are all blind to the treatment allocation. PRIVENT was the world's largest study investigating if long-term antibiotics prevent urinary tract infections in children.

PRIVENT is now complete & the results of this study have now been published.

Craig JC, Simpson JM, Williams G, Reynolds G, McTaggart S, Hodson E, Carapetis j, Cranswick N, Irwig L, Caldwell P, Roy LP. Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children. New England Journal of Medicine 2009 Oct 29;361(18):1748-59.